These guys make lubes specifically for anal sex and they've been know what sort of dark sorcery they used to make a water-based lube that. While silicone-based lubes are often best for anal sex since they last Better yet, you can use it with silicone anal toys, such as butt plugs or anal beads. It lasts what feels like forever, making it an ideal choice for anal. What are the best lubricants for anal sex? But since silicone breaks down silicone, these lubes are not safe to use with silicone toys, unless noted as “safe”.